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Shane R Wilkinson Selected Research

Nifurtimox

9/2017Characterisation of the fumarate hydratase repertoire in Trypanosoma cruzi.
4/2013Evaluating 5-nitrofurans as trypanocidal agents.
4/2011Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites.
1/2011Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.
4/2008A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.

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Shane R Wilkinson Research Topics

Disease

12Chagas Disease (American Trypanosomiasis)
06/2020 - 11/2007
10African Trypanosomiasis (Nagana)
11/2017 - 01/2008
8Infections
10/2017 - 09/2008
3Parasitic Diseases (Parasitic Disease)
09/2017 - 04/2008
2Neoplasms (Cancer)
10/2017 - 05/2015
2Hypersensitivity (Allergy)
04/2013 - 03/2010
1Communicable Diseases (Infectious Diseases)
10/2017
1Cutaneous Leishmaniasis
10/2017
1Trypanosomiasis
10/2017
1Persistent Infection
04/2015
1Leishmaniasis
10/2013
1Visceral Leishmaniasis (Kala Azar)
02/2012
1Neglected Diseases
12/2011
1Alzheimer Disease (Alzheimer's Disease)
12/2010

Drug/Important Bio-Agent (IBA)

6Pharmaceutical PreparationsIBA
06/2020 - 01/2008
6ProdrugsIBA
10/2017 - 01/2011
6benzonidazole (benznidazole)IBA
09/2017 - 04/2008
5NifurtimoxIBA
09/2017 - 04/2008
3EnzymesIBA
05/2015 - 03/2010
2trypanothioneIBA
11/2017 - 09/2008
2LuciferasesIBA
01/2014 - 10/2010
2Antiparasitic Agents (Antiparasitics)IBA
04/2013 - 02/2012
1quinone (benzoquinone)IBA
10/2017
1diphenyl (biphenyl)IBA
11/2016
1AcetamidesIBA
11/2016
15-nitrothiazoleIBA
02/2016
1Mechlorethamine (Nitrogen Mustard)FDA Link
05/2015
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
04/2015
1VaccinesIBA
12/2013
1NADH dehydrogenase (quinone)IBA
10/2013
1Flavin Mononucleotide (FMN)IBA
10/2013
1NitroreductasesIBA
10/2013
1Eflornithine (Ornidyl)FDA Link
04/2013
1DiaminesIBA
02/2012
1azomycinIBA
01/2012
1AminesIBA
12/2011
1fexinidazoleIBA
01/2011
1CopperIBA
12/2010
1Amyloid (Amyloid Fibrils)IBA
12/2010
1IonsIBA
12/2010
1Amyloid beta-PeptidesIBA
12/2010
1AntioxidantsIBA
09/2008
1VitaminsIBA
11/2007

Therapy/Procedure

4Therapeutics
10/2017 - 04/2011
2Drug Therapy (Chemotherapy)
05/2015 - 01/2010